Nucleotide probes of DNA polymerases.
نویسندگان
چکیده
منابع مشابه
Structures of DNA polymerases caught processing size-augmented nucleotide probes.
The integrity of the genome relies primarily on the ability of DNA polymerases to efficiently catalyze selective DNA synthesis according to the Watson–Crick rule in a templatedirected manner during DNA replication, repair, and recombination. Remarkably, some DNA polymerases achieve selective information transfer to the offspring in line with the Watson–Crick rule with intrinsic error rates as l...
متن کاملA reexamination of the nucleotide incorporation fidelity of DNA polymerases.
Intensive study has been devoted to understanding the kinetic and structural bases underlying the exceptionally high fidelity (low error frequencies) of the typical DNA polymerase. Commonly proposed explanations have included (i) the concept of fidelity check points, in which the correctness of a nascent base pair match is tested at multiple points along the reaction pathway, and (ii) an induce...
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All living organisms are defined by their genetic code encrypted in their DNA. DNA polymerases are the enzymes that are responsible for all DNA syntheses occurring in nature. For DNA replication, repair and recombination these enzymes have to read the parental DNA and recognize the complementary nucleotide out of a pool of four structurally similar deoxynucleotide triphosphates (dNTPs) for a gi...
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The DNA Polymerase Database (Polbase) is intended to compile the wealth of existing DNA polymerase information from public and private records into an open, searchable database.
متن کاملEukaryotic DNA Polymerases
Themajor function ofDNApolymerases is to replicate the genome and thus to allow transmission of genetic information fromone generation to the next. In eukaryotic cells, this takes place during a discrete period (S phase) of interphase, and replicated chromosomes are subsequently segregated to daughter cells during mitosis. As well as replicating DNA, polymerases help to maintain the integrity o...
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 1996
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.1996_4522